Postpartum Seizures: Cerebral Venous Sinus Thrombosis, Case Report

Case Report

Austin J Obstet Gynecol. 2021; 8(2): 1167.

Postpartum Seizures: Cerebral Venous Sinus Thrombosis, Case Report

Ahmed AAH*

Medical Intern at Wad Medani Teaching Hospital, Sudan

*Corresponding author: Asim Ahmed Hussein Ahmed, Medical Intern at Wad Medani Teaching Hospital, Wad Medani, Gezira State, Sudan

Received: February 05, 2021; Accepted: February 25, 2021; Published: March 04, 2021

Abstract

Cerebral venous sinus thrombosis is of rarity during pregnancy, and it is included in the differential diagnosis of a woman presenting with seizures during pregnancy and puerperium. Here we report a case of young lady who developed Cerebral Venous Sinus Thrombosis (CVST) 6 days after delivery, presented with a chief complain of loss of consciousness and high grade fever with recent past history of severe occipital headache and generalized convulsions, which progressed into left sided weakness. Magnetic Resonance Imaging (MRI) / Magnetic Resonance Venography (MRV) demonstrated filling defects at the right transverse and sigmoid sinuses. The patient was started on Enoxaparin and warfarin. The patient kept on improving gradually and was discharged after 24 days in a good condition.

Keywords: Postpartum; Venous thrombosis; Cerebral; Seizures; Case report; Pregnancy; Puerperium

Introduction

Cerebral venous sinus thrombosis is a rarely encountered condition during pregnancy, however, pregnancy itself, puerperium, coagulopathies, cerebral infections, malignancies, dehydration and the Pill are amongst its commonest causes [1,2]. Signs and symptoms of the disease include headache, blurring of vision, focal and/or generalized convulsions and papilledema [1-3].

Case Presentation

25 years old, house wife, Para 2 delivered by emergency cesarean section due to 1 previous scar in labour on top of major degree contracted pelvis on 14th of July 2019. The outcome was a 3.2 kg male baby, now alive and well. Both pregnancy and delivery were without complications. She was referred to Wad Medani Obstetrics and Gynecology hospital, Gezira state, Sudan on 22nd of July 2019 with a chief complain of loss of consciousness and high grade continuous fever 6 days postoperatively. The condition was preceded by generalized tonic clonic seizures, thrice, not preceded by aura after which the patient was postictal and lost her sphincters control. The relatives reported a history of severe occipital headache not relieved by over-the-counter paracetamol. They denied a history of blurred vision and projectile vomiting. They also denied a past history of epilepsy.

Physical examination revealed a comatose woman with a Glasgow Coma Scale (GCS) of 8/15, not pale, jaundiced or cyanosed. Vital signs were: pulse 90 beats/min, blood pressure 130/80 mmHg, respiratory rate 30 cycle/min and a temperature of 37.9 degree Celsius. Cardiovascular system and abdominal examination was normal, the wound site was clean and intact. Chest examination revealed dullness on percussion and coarse crepitation all over the chest. Neurological examination showed hypotonia and hyporeflexia in both upper limbs, and the lower limbs were dorsi-flexed and laterally rotated and both hypotonic and hyporeflexic. Power, sensation and coordination were difficult to be assessed.

Baseline routine investigations were requested including (Table 1): Blood film for malaria: negative, hemoglobin level: 10.8 g/dl, platelet count 269*103, white cell count: 9.3*103, random blood glucose 121 mg/dl, renal function test: blood urea 9.9 mmol/l, serum creatinine 0.5 mmol/l, coagulation profile: International Normalized Ratio (INR) 1.3, Prothrombin Time (PT) 17 seconds, liver function test came normal, urine analysis was clear except for 6 – 8 pus cells/ HPF and uncountable red blood cells. Computed Tomography (CT) was done which showed hyper-dense superior sagittal sinus features that are suggestive of Venous Sinus Thrombosis (VST) and advised further imaging studies (Figure 1). Magnetic Resonance Imaging (MRI) showed high signal intensity at the right occipital area, features that are suggestive of cerebral infarcts (Figure 2). Magnetic Resonance Venography (MRV) revealed a filling defect at the right transverse and sigmoid sinuses and the right internal jugular vein is not opacified, features that are suggestive of venous thrombosis (Figure 3). The final impression was a right cerebral infarct and right sinus thrombosis. The patient was admitted to the High Dependency Unit (HDU), a nasogastric tube was fixed with 300ml feed every 4 hours and a fluid maintenance of 500 ml every 8 hours with dextrose in normal saline. The patient was covered by injectable antibiotics (ceftriaxone 1g IV BID and metronidazole 500mg drip TDS) proton pump inhibitors (pantoprazole 40mg IV) and paracetamol 500mg drip BID. The patient was also started on phenytoin loading (3 ampules in 500ml normal saline drip over 24 hours) and maintenance doses (1 ampule in 500ml every 8 hours) and dexamethasone 10mg BID. Next day the patient was started on Enoxaparin 6000 IU subcutaneously twice a day and Aspirin 300mg Once Daily (OD) through the NG tube for 3 days then replaced by clopidogrel 75mg OD. Five days following admission, the patient started to regain her consciousness and was found to have left sided weakness. She was discharged after 24 days in good condition (GCS 15) and oral warfarin 5 mg OD (INR 1.3). She was able to control over her sphincters and able to walk with support. Then one month after discharge, warfarin dose was reduced to 3mg OD according to the INR result (INR 2.3).